FOXA1 is a determinant of drug resistance in breast cancer cells
نویسندگان
چکیده
منابع مشابه
Cancer Stem Cells and Multiple Drug Resistance in Breast Cancer*
Million of new cancer patients are diagnosed each year and over half of these patients die from this disease. As the second leading cause of cancer deaths, breast cancer in estimated to be diagnosed in over one million people worldwide and to cause more than 400,000 deaths each year. Chemotherapy is part of a successful treatment to many cases; however, the development of multidrug resistance (...
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Several studies have demonstrated that the isolated side population (SP) cells from solid tumors exhibit cancer stem cell‑like properties, and are responsible for drug resistance during chemotherapy and tumor recurrence. In the current study, cancer stem cell‑like SP cells were isolated in the MDU‑22 breast cancer cell line using the Hoechst‑33342 dye exclusion technique. It was observed that S...
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چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولDrug delivery by a self-assembled DNA tetrahedron for overcoming drug resistance in breast cancer cells.
A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to...
متن کاملFunctional miRNAs in breast cancer drug resistance
Owing to improved early surveillance and advanced therapy strategies, the current death rate due to breast cancer has decreased; nevertheless, drug resistance and relapse remain obstacles on the path to successful systematic treatment. Multiple mechanisms responsible for drug resistance have been elucidated, and miRNAs seem to play a major part in almost every aspect of cancer progression, incl...
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ژورنال
عنوان ژورنال: Breast Cancer Research and Treatment
سال: 2021
ISSN: 0167-6806,1573-7217
DOI: 10.1007/s10549-020-06068-5